Drug Uses

Denavir is a topical antiviral medication used for recurrent cold sores (herpes labialis) on the lips and face in otherwise healthy adult patients. Denavir topical may also be used for purposes other than those listed in this medication guide.

How Taken

Apply Denavir every two hours during waking hours for four days to your cold sore with your finger or a cotton swab. Wash hands with soap and water to prevent it from coming into contact with your eyes or other areas; to prevent irritation and to prevent spread of the herpes virus.

Warnings/Precautions

Denavir is a topical cream that is applied externally on the lips and face. Do not apply Denavir on mucous membranes inside the mouth, nose, genital or rectal areas. Denavir topical is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby. Do not use Denavir topical during pregnancy without first talking to your doctor. It is not known whether Denavir topical passes into breast milk. Do not use Denavir topical if you are breast-feeding a baby without first talking to your doctor.

Missed Dose

Use the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and use only your next regularly scheduled dose.

Possible Side Effects

Serious side effects have not been reported with the use of Denavir topical. Other less serious side effects may be more likely to occur. Continue to use Denavir topical and talk to your doctor if you experience: headache; local numbness or tingling where the cream is applied; changes in taste; rash; irritation at the application site. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Store at controlled room temperature, 20°-25°C (68°-77°) away from moisture and heat.

Overdose

An overdose of Denavir topical is unlikely to threaten life. If an excessive amount of the cream has been used, or if the cream has been ingested, contact a poison control left or an emergency room for advice.

More Information

Do not use other topical medications to treat the same area at them same time as Denavir topical, unless otherwise directed by your doctor. No other medicines have been reported to interact with Denavir topical. Talk to your doctor or pharmacist before taking other prescription or over-the-counter medications during treatment with Denavir topical.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Q: What happens when I submit my Denavir order?
A: Your order is dispatched through our order system to a licensed physician who will review the information you have submitted and approve or decline your request of Denavir. When your order is approved, the physician will then write your prescription and our ordering system will ensure that it is sent to the pharmacy where it will be filled and shipped.


Herpes infections down, but still are a concern
CHICAGO - Nearly 25 years after a news magazine declared that an epidemic of genital herpes threatened to undo the sexual revolution, a new study finds an encouraging decline in the percentage of people infected with the herpes virus.
Back in 1982, a Time cover story headlined “The New Scarlet Letter” sounded an alarm that seems mild now compared to concern over another sexually transmitted lifetime infection, the AIDS virus.
The new study shows a 19 percent drop since 1994 in the percentage of Americans ages 14 to 49 testing positive for herpes type 2, the most common cause of the recurring painful sores of genital herpes. The declines were especially pronounced among young people.
The findings, appearing in Wednesday’s Journal of the American Medical Association, represent biological evidence of a decrease in risky sexual behavior among adolescents, said lead author Dr. Fujie Xu of the Centers for Disease Control and Prevention.
“Overall, this is good news. There is a decrease occurring among all youth, males and females, and in all racial groups,” Xu said. “That’s very encouraging.”
But herpes is still uncomfortably common. Despite the decline, blood tests of more than 11,000 people found 11 percent of men and 23 percent of women carry the genital herpes, or type 2, virus. Among people in their 20s, the infection rate was almost 11 percent.
Ironically, the rates have dropped back to about where they were when Time ran its cover story, said study co-author Dr. Stuart Berman of the CDC.
“If it was a scarlet letter then, I don’t know what you call it now and there’s more HIV around,” Berman said. Herpes greatly increases the chances of infection with HIV, the virus that causes AIDS.
“It’s still an epidemic,” said Dr. Tom Cherpes of the University of Pittsburgh School of Medicine, who was not involved with the study. “The fact that there’s a trend downward should not be construed by anybody that herpes is under control.”
In addition, 56 percent of men and 60 percent of women tested positive for the oral herpes virus, type 1, which is best known as the culprit behind cold sores, but can spread to the genitals through oral sex. Type 1 may be causing more genital infections in some groups, such as college students, Xu and Berman said.
Herpes can be treated with antiviral drugs, which can help prevent flare-ups and reduce the risk of spreading it to others. Condoms can help lower the risk of transmission, although they’re not foolproof. Infected people are contagious even without symptoms.
The study was funded by the CDC. A previous CDC report in 1997 found a 30 percent increase in herpes infection since the late 1970s.
“This new data really reverses the trend,” said study co-author Francis Lee of Emory University.
Dr. Kenneth Fife of the Indiana University School of Medicine, who was not involved in the study, noted that rates of infection are still disproportionately high among women and blacks. The study found 42 percent of blacks tested positive for herpes type 2, a decline of only 4 percent since 1994.
“Maybe we’ve finally gotten through to the young people that they need to change their behavior,” Fife said. “We still see plenty of genital herpes. There are adolescents who are becoming infected.”

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